Detail Increased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity are Associated with Hepatitis C Virus Clearance (from Journal of Virology, 2008, Vol. 82 (6), 3147-3153) Bibliografi Author: Yerly, Daniel ; Heckerman, David ; Allen, Todd M. ; Chisholm III, John V. ; Faircloth, Kellie ; Linde, Caitlyn H. ; Frahm, Nicole ; Timm, Joerg ; Pichler, Werner J. ; Cerny, Andreas ; Brander, Christian Topik: Hepatitis C; Validation ref - 20 Bahasa: (EN )     Penerbit: American Society for Microbiology     Tempat Terbit: Washington, D.C.    Tahun Terbit: 2008     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 2252-07.pdf (779.56KB; 0 download) Abstract Hepatitis C virus (HCV) clearance has been associated with reduced viral evolution in targeted cytotoxic T-lymphocyte (CTL) epitopes, suggesting that HCV clearers may mount CTL responses with a superior ability to recognize epitope variants and prevent viral immune escape. Here, 40 HCV-infected subjects were tested with 406 10-mer peptides covering the vast majority of the sequence diversity spanning a 197-residue region of the NS3 protein. HCV clearers mounted significantly broader CTL responses of higher functional avidity and with wider variant cross-recognition capacity than nonclearers. These observations have important implications for vaccine approaches that may need to induce high-avidity responses in vivo. [validation ref - 20] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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