Effects of Renal Disease on Pharmacokinetics  

Oleh:

Atkinson, Arthur J., (Jr.) ; Reidenberg, Marcus M.

Jenis: Article from Books - E-Book
Dalam koleksi: Principles of Clinical Pharmacology, page 51-58.
Fulltext: Effects of Renal Disease on Pharmacokinetics.pdf (238.48KB)

Isi artikel

A 67-year-old man had been functionally anephric, requiring outpatient hemodialysis for several years. He was hospitalized for revision of his arteriovenous shunt and postoperatively complained of symptoms of gastroesophageal reflux. This complaint prompted institution of cimetidine therapy. In view of the patient’s impaired renal function, the usually prescribed dose was reduced by half. Three days later, the patient was noted to be confused. An initial diagnosis of dialysis dementia was made and the family was informed that dialysis would be discontinued. On teaching rounds, the suggestion was made that cimetidine be discontinued. Two days later the patient was alert and was discharged from the hospital to resume outpatient hemodialysis therapy.

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