Estrogen plus progestin treatment: effect of different progestin components on serum markers of apoptosis in healthy postmenopausal women  

Oleh:

Karaflou, Maria ; Kaparos, George ; Rizos, Demetrios

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 94 no. 06 (Nov. 2010), page 2399-2401.
Topik: Estrogen; progestin; drospirenone; norethisterone; hormone therapy; Fas; FasL; cyt-c; apoptosis

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

One hundred healthy postmenopausal women were randomly assigned to receive 17ß-E2 1 mg/drospirenone 2 mg or 17ß-E2 1 mg/norethisterone acetate 0.5 mg for 6 months, and circulating soluble Fas, soluble Fas ligand, and cytochrome c were measured at baseline and at 6 months in 87 women who completed the study. Although cytochrome c levels were undetectable, circulating soluble Fas/soluble Fas ligand ratio decreased in both groups, suggesting a decrease in ligand-mediated apoptosis.

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