Perbandingan Premedikasi Dexmetomidine 0,6 µg/kgBB i.v. dan Pemberian Lidokain 1,5 mg/kgBB i.v. Praintubasi dalam Mencegah Kenaikan Tekanan Intraokuler pada Laringoskopi-Intubasi  

Oleh:

Sawastuti, Iris ; Abubakar, Muhdar ; Suryono, Bambang

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Berkala Kesehatan Klinik vol. 12 no. 02 (Dec. 2006), page 96-106 .
Topik: Dexmedetomidine - 0.2 Adrenergic Agonist – Tracheal lntubations -Intraocular Pressure

Ketersediaan

Perpustakaan FK Nomor Panggil: B25.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Laryngoscopy-intubation procedure could raise the homodynamic response. It is said that cardiovascular response will raise Intra Ocular too with unknown mechanism. One of the ways to control lOP rise is use Dexmedetomidine (a selective 0.2-drenoreceptor agonist). Objective: To compare the effect on intra ocular pressure (lOP) between premedication Dexmedetomidine 0.6µg/kgBW iv and Lidocaine 1.5 mg/kgBW iv pre and post intubations. Method: The design is double blind randomized clinical trial study on non-eye surgery patients with normal lOP who underwent elective operation, performed under general anesthesia with tracheal intubations at COT of Sardjito General Hospital. 70 patients, ages 18-50 years old, the physical status ASA I_II were divided randomly into 2 groups, consist of 35 patients on each. Result: Pre-intubations after its onset, the lOP of the Dex group getting decrease 2.78 mmHg (16.98%), and the Lido group getting decrease 0.302 mmHg (1.88%). First minute intubations the Dex groups getting increase 1.19 mmHg (7.26%) from baseline, however the Lido groups getting increase 4.3 mmHg (28.7%) from baseline, the differences was statistically significant (p<0.05). The 3rd, 5th and 10th minutes after intubations the both groups getting decrease with almostthe same value, the Dex group 17.75 -7.84 -7.97 (%) and the Lido group 21- 8.28- 8.21 (%) but the Dex group still reflects lower pressure than Lido, and the differences were statistically significant (P<0.05). Conclusion: The Dexmedetomidine 0,6 µg/kgBW as premedication leads to prevent the increase of intraocular pressure better and statistically significant (p<0.05) than the administration of Lidocain 1.5 mg/kgBW iv 4 minutes before intubations at laryngoscopy-intubation on the normal lOP.

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