Detail Perbandingan Efektivitas Kerja Live, Attenuated, Influenza Vaccine (LAIV) dan Inactivated Influenza Vaccine (IIV) dalam Perlindungan terhadap Influenza pada Orang Dewasa Bibliografi Author: ANGKASA, JUDY RANITA ; Angelina, Yohanna (Advisor); Tanzil, Kunadi (Examiner) Topik: INFLUENZA VACCINE; LAIV; IIV; vaccine effectiveness; influenza vaccine; influenza; efektivitas kerja; vaksin influenza; influenza Bahasa: (ID )     Penerbit: Fakultas Kedokteran Unika Atma Jaya     Tempat Terbit: Jakarta Utara    Tahun Terbit: 2015     Jenis: Theses - Karya Tulis Ilmiah Kedokteran (KTI-FK) Fulltext: KTI Judy.pdf (953.71KB; 14 download) Ketersediaan Perpustakaan FK Nomor Panggil: KTI-FK-815 Non-tandon: tidak ada Tandon: 1  Lihat Detail Induk Abstract Background. Influenza is an acute disease that attacks the respiratory system. Because it is highly contagious and can easily mutate, influenza virus frequently causes pandemic and endemic worldwide. One of the many ways to prevent these pandemic and endemic is by vaccination. There are two methods of vaccination available (LAIV and IIV), and both differ in the mode of administration as well as how they work in the human body. Objectives. The aim of this study is to compare the effectiveness of LAIV and IIV in terms of protection against influenza in the adult population. Methodology. This systematic review references several medical textbooks, medical research papers, as well as official scientific websites which are related to the topic. The research papers used in this paper consist of papers that have been published since five years ago, commencing from the year 2009. Results and Conclusion. Each type of vaccination has advantages and disadvantages. LAIV, because the administration pathway resembles influenza infection in general, can induce a local immune response in the nasopharyngeal mucosa and thus can better protect the upper respiratory tract from infection. In terms of crossprotection, LAIV is more superior than IIV. The dominant immune responses in LAIV consist of an increase in cytotoxic T cells (CD8) as well as an increase in mucosal IgA. IIV, because it is administered parenterally, can induce a systemic immune response and thus can better protect the lower respiratory tract from infection. Increased serum antibodies induced by IIV is significant, with serum IgG as the dominant antibody. Suggestions. The suggestions to further improve this research consist of conducting a comparative literature that discusses the effectiveness of LAIV and IIV in children, as well as conducting more clinical trials comparing the effectiveness of these two types of vaccine in the future. Also, the writer suggests on conducting comparative literature studies which focuses on IIV which were given intranasally with LAIV. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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