Perbedaan Nilai Kualitas Hidup Penderita Gagal Ginjal yang Menjalani Hemodialisis Berdasarkan Kadar Malondialdehid dan Interleukin-6  

Oleh:

Surya S, LP. Ike ; Sjabani, Moch ; Kuswadi, Iri

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Berkala Kesehatan Klinik vol. 14 no. 02 (Dec. 2008), page 76-80 .
Topik: oxidative stress-chronic inflammation-routine haemodialysis-MDA- IL-6

Ketersediaan

Perpustakaan FK Nomor Panggil: B25.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: Oxidative stress occurs when there is imbalance between free radical and antioxidant defends mechanism. Malondialdehyde (MDA) plasma is lipid peroxides product frequently used to evaluate oxidative stress. Physiologically MDA levels is less than 4 µmol/L. Interleukin 6 (IL-6) is suggested to have in the pathophysiology of inflammation in patients with kidney disease and have relationship with morbidity and mortality of chronic kidney disease. The objective of this study is to evaluate the relationship of inflammation marker with quality of life chronic kidney disease patients undergoing routine haemodialysis in Dr. Sardjito Hospital. Methods: This is a cross sectional study which involves 72 patients. The subjects are divided in two groups MDA plasma levels e" 4 µmol/L, (51 subjects) and < 4 µmol/L (21 subjects), IL-6 levels e"9,96 mg/L (47 subjects) and < 9,96 mg/L (25 subjects), in relation with quality of life measured by modified KDQOL SF-36. Result and conclusion: There is significant correlation between IL-6 levels e" 9,96 mg/L, with SF-36 score for symptoms (p=0.013 95% CI 6.9 - 25.8), work status (p=0.04 95% CI 0.8 - -33.1), pain (p=0.013 95% CI 3.9 - 33.3), energy (p=0.013 95% CI 2.6 - 21.6), and physical health score (p=0.029 95% CI 0.4 - 7.3), social support (p=0.032 95% Cl1.0 - 21.9). There is significant association between MDA plasma levels e" 4µmol/L with SF-36 component satisfaction (p=0.013 95% Cl1.7 -13.9). There is significant relationship between MDA plasma level e" 4 µmol/L and IL-6 e" 9,96 mg/L with SF-36 component sleep (p=0.007 ; 95% CI=6.6 - 39.0). This study give proof prove the relationship between oxidative stresses, inflammation marker with the lower quality of life on the chronic kidney disease patients undergoing routine haemodialysis.

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