Kadar Leptin pada populasi non Diabetes dengan dan tanpa Non Alcoholic Fatty Liver (NAFL)  

Oleh:

Sofia, Noor Asyiqah ; Nurdjanah, Siti ; Ratnasari, Neneng

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Berkala Kesehatan Klinik vol. 15 no. 01 (Jun. 2009), page 49-55 .
Topik: leptin - non diabetic - non alcoholic fatty liver

Ketersediaan

Perpustakaan FK Nomor Panggil: B25.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: Non alcoholic fatty liver disease (NAFLD) is a prevalent condition associated with obesity and insulin resistance. Leptin is an adipokine which plays role in decreasing food intake and controlling energy utilization. The role of leptin in pathogenesis of NAFLD remains unclear. Former studies associated with the role of leptin in NAFL are never conducted in diabetic patients. Objective: The objective of this study is to analyze the difference of leptin level in non diabetic population between subjects with and without non alcoholic fatty liver disease. Methods: This is a non matching case control study in general check up polyclinic Dr.Sardjito Hospital Yogyakarta. The inclusion criteria are aged 30-60 years old, no history of both alcohol consumption more than 20 gr/day and diabetes mellitus. The exclusion criteria are viral hepatitis (B and C), rapid weight loss, steroid therapy, and pregnancy. Diagnosis of NAFL is based on bright liver imaging from ultrasonography. Result and Conclusion: There are 48 subjects consist of 23 subjects with NAFL and 25 subjects without NAFL. Mean of leptin level in NAFL group is higher than non NAFL group and this difference is statistically significant (20.29±15.73 ng/mL and 12.27±10.1 ng/mL: p=0.040). The conclusion of this study is leptin level significantly higher in non diabetic population with NAFL compared with non NAFL.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali