Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function  

Oleh:

Frid, Anders ; Sterner, Gunnar N. ; Londahl, Magnus

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 33 no. 06 (Jun. 2010), page 1291-1293.
Topik: Type 2 Diabetes; Renal Function

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE To study trough levels of metformin in serum and its intra-individual variation in patients using a newly developed assay. RESEARCH DESIGN AND METHODS Trough serum levels of metformin were measured once using liquid chromatography–tandem mass spectrometry (LCMSMS) in 137 type 2 diabetic patients with varying renal function (99 men) and followed repeatedly during 2 months in 20 patients (16 men) with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 body surface. RESULTS Patients with eGFR >60, 30–60, and <30 ml/min/1.73 m2 had median trough metformin concentrations of 4.5 µmol/l (range 0.1–20.7, n = 107), 7.71 µmol/l (0.12–15.15, n = 21), and 8.88 µmol/l (5.99–18.60, n = 9), respectively. The median intra-individual overall coefficient of variation was 29.4% (range 9.8–74.2). CONCLUSIONS Determination of serum metformin with the LCMSMS technique is useful in patients on metformin treatment. Few patients had values >20 µmol/l. Metformin measurement is less suitable for dose titration.

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