Plasma 25-Hydroxyvitamin D Concentration and Risk of Incident Type 2 Diabetes in Women  

Oleh:

Pittas, Anastassios G. ; Qi Sun ; Manson, JoAnn E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 33 no. 09 (Sep. 2010), page 2021-2023 .
Topik: Type 2 Diabetes Mellitus; Women

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE To determine the association between 25-hydroxyvitamin D (25-OHD) concentration and risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS In a nested case-control study conducted among 608 women with newly diagnosed type 2 diabetes and 559 control subjects in the Nurses' Health Study, we measured the association between baseline plasma 25-OHD concentration and risk of incident diabetes. RESULTS After adjusting for matching factors and diabetes risk factors, including BMI, higher levels of plasma 25-OHD were associated with a lower risk for type 2 diabetes. The odds ratio for incident type 2 diabetes in the top (median 25-OHD, 33.4 ng/ml) versus the bottom (median 25-OHD, 14.4 ng/ml) quartile was 0.52 (95% CI 0.33–0.83). The associations were consistent across subgroups of baseline BMI, age, and calcium intake. CONCLUSIONS Plasma 25-OHD concentration was associated with lower risk of incident type 2 diabetes in women.

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