Hepatocyte Growth Factor and Clinical Diabetes in Postmenopausal Women  

Oleh:

Rajpathak, Swapnil N. ; Wassertheil-Smoller, Sylvia ; Crandall, Jill

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 33 no. 09 (Sep. 2010), page 2013-2015 .
Topik: Hepatocyte Growth Factor; Postmenopausal Women

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

OBJECTIVE To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS A cross-sectional analysis among 892 postmenopausal women within the Women's Health Initiative Observational Study (WHI-OS). RESULTS HGF levels positively correlated with BMI and homeostasis model assessment for insulin resistance. In the multivariable analysis comparing the highest tertile with the lowest tertile of HGF, the odds ratio for prevalent diabetes was 2.47 (95% CI [1.12–5.47], P for trend = 0.014) after accounting for age, race, BMI, and other risk factors for diabetes. CONCLUSIONS HGF levels are associated with the presence of type 2 diabetes in postmenopausal women. Future studies should consider the prospective evaluation of the association of HGF with the development of type 2 diabetes.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali