Tumour Necrosis Factor-alpha Polymorphisms and Hepatocellular Carcinoma: a Meta-analysis  

Oleh:

Qin, H ; Liu, B. ; Shi, T

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 03 (May 2010), page 760-768.
Topik: hepatocellular carcinoma; tumour necrosis factor-a; gene polymorphism; meta-analysis

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. To summarize the quantitative association between polymorphisms of the tumour necrosis factor-alpha (TNFA) gene and HCC, a meta-analysis of relevant studies was performed. Ten case–control studies involving 1421 HCC cases were identified from the Medline®, Embase® and Current Contents® databases. Combined results based on all studies showed that patients with HCC had a significantly lower frequency of the TNFA gene polymorphism –308GG than healthy controls. When stratifying for race, results were similar among Asians and Caucasians. When comparing with hepatitis B virus infection cases, no statistical association was found. This meta-analysis suggests that TNFA –308GG gene polymorphism is associated with a modest decrease in the risk of HCC.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali