Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914  

Oleh:

Stratton, Pamela ; Levens, Eric D. ; Hartog, Beth

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 06 (Apr. 2010), page 2035-2041.
Topik: CDB-2914; endometrium; luteal phase; single dose; selective progesterone receptor modulators

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To test potential contraceptive mechanisms of the selective P receptor modulator CDB-2914 in the early luteal phase. Design Prospective randomized clinical trial. Setting Clinical research center. Patient(s) Fifty-six women with regular cycles. Intervention(s) Women received a single dose of CDB-2914 (10, 50, or 100 mg) or placebo given after ovulation and within 2 days of the LH surge. Four to 6 days later, a transvaginal ultrasound scan measured endometrial thickness, and an endometrial biopsy specimen was obtained. Main Outcome Measure(s) The endometrium was evaluated by thickness and by immunohistochemical analysis for P-dependent markers; safety laboratory tests were performed, and E2 and P levels were obtained. Result(s) CDB-2914 caused a significant dose-dependent decrease in endometrial thickness, an increase in glandular P receptors, and a decrease in peripheral node addressins. Estradiol and P levels and menstrual cycle timing were not altered. No adverse effects were observed. Conclusion(s) The alteration in endometrial thickness and P-dependent markers of implantation in the absence of changes in hormone levels and cycle length suggests that CDB-2914 may have contraceptive properties.

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