Metabolism of triglyceride-rich lipoproteins and lipid transfer to high-density lipoprotein in young obese and normal-weight patients with polycystic ovary syndrome  

Oleh:

Rocha, Michelle P. ; Maranhao, Raul C. ; Seydell, Talita M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 06 (Apr. 2010), page 1948-1956.
Topik: Polycystic ovary syndrome; insulin resistance; triglyceride-rich lipoprotein remnants; atherosclerosis; transfer lipoproteins

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To clarify whether the metabolism of triglyceride-rich lipoproteins and lipid transfer to high-density lipoprotein (HDL) are altered in patients with polycystic ovary syndrome (PCOS). Design Case–control study. Setting Endocrinology clinics. Patient(s) Eight normal-weight (NW) and 15 obese (Ob) patients with PCOS were compared with 10 NW and 10 Ob women without PCOS paired for age and body mass index. Intervention(s) Determination of triglyceride-rich lipoprotein metabolism and lipid transfer to HDL. Main Outcome Measure(s) Participants were injected triglyceride-rich emulsions labeled with 14C-cholesteryl esters and 3H-triglycerides and the fractional clearance rate (FCR, in min-1) of labels was determined. Lipid transfer from artificial nanoemulsions to HDL was performed by incubating radioactively labeled lipid nanoemulsions with plasma during 1 hour, followed by radioactive counting of HDL-containing supernatant after chemical precipitation. Result(s) Lipolysis estimated by triglyceride FCR was equal in PCOS groups (NW = 0.043 ± 0.032, Ob = 0.033 ± 0.009) and respective controls (NW = 0.039 ± 0.015, Ob = 0.044 ± 0.019). However, the remnant removal as estimated by cholesteryl ester FCR was reduced in both PCOS groups (NW = 0.005 ± 0.006, Ob = 0.005 ± 0.005) compared with controls (NW = 0.016 ± 0.006, Ob = 0.011 ± 0.072). Lipid transfer rates were not different among groups, but triglyceride transfer rates were positively correlated with homeostasis model assessment estimate of insulin resistance in PCOS. Conclusion(s) PCOS patients showed decreased removal of atherogenic remnants even when fasting glucose was <100 mg/dL. This reinforces the usefulness of the measures taken to prevent cardiovascular events in PCOS patients.

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