Relationship between interleukin-6 levels and ambulatory blood pressure in women with polycystic ovary syndrome  

Oleh:

Kaya, Cemil ; Pabuccu, Recai ; Koca, Cemile

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 94 no. 04 (Sep. 2010), page 1437-1443.
Topik: PCOS; ABP; IL-6; CRP; NO

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To determine 24-hour ambulatory blood pressures (ABP) in patients with polycystic ovary syndrome (PCOS) and its relationship with interleukin-6 (IL-6). Design Prospective controlled study. Setting University hospital. Patient(s) Fifty-four PCOS patients. Intervention(s) Ambulatory blood pressure monitoring was conducted. Anthropometric, hormonal, metabolic, and inflammatory parameters, including plasma IL-6, C-reactive protein (CRP), fibrinogen, and nitric oxide (NO), were measured in each subject. Main Outcome Measure(s) Ambulatory blood pressure and plasma IL-6, CRP, fibrinogen, and NO. Result(s) Serum IL-6 levels of PCOS women in the highest systolic blood pressure (SBP) quartile were significantly higher than those of women in the lowest SBP quartile. The high serum IL-6 levels (serum IL-6 level =5.1 pg/mL) were associated with a higher probability of raised SBP (=126 mm Hg), with an odds ratio of 2.2 (95% confidence interval 0.8–7.9). The systolic and diastolic (DBP) blood pressures were significantly related to serum IL-6 levels. The IL-6 levels were positively and significantly correlated with serum CRP levels. Interleukin-6 and CRP were negatively and significantly correlated with serum NO levels. Conlusion(s) The results suggest that raised plasma IL-6 levels may be related to ambulatory SBP and DBP in PCOS.

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