Detail Pengaruh Akar Pasak Bumi (Eurycoma longifolia,Jack.) terhadap Plasmodium Falciparum Bibliografi Author: PATRICIA, YOSHIE ; Kurniawan, Sandy Vitria (Advisor); Lembar, Stefanus (Advisor); Joprang, Freggy Spicano (Examiner) Topik: HERBAL MEDICINE; Eurycoma longifolia; Jack. root; antimalarial; Akar pasak bumi; antimalaria Bahasa: (ID )     Penerbit: Fakultas Kedokteran Unika Atma Jaya     Tempat Terbit: Jakarta Utara    Tahun Terbit: 2015     Jenis: Theses - Karya Tulis Ilmiah Kedokteran (KTI-FK) Fulltext: KTI Yoshie.pdf (1.6MB; 7 download) Ketersediaan Perpustakaan FK Nomor Panggil: KTI-FK-800 Non-tandon: tidak ada Tandon: 1  Lihat Detail Induk Abstract Malaria is a disease mostly found in tropic area. The incidence of malaria becomes increasing in number especially by multi drug resistant P. falciparum. The biggest treatment challenge found in endemic area. It is important to find a new antimalarial drug with different in chemical structure and mechanism of action. Continueous discovering of new antimalarial drugs must be done because P.falciparum has shown itself capable of developing resistance to nearly all used antimalarial drugs. One of plants used traditionally as a medicine to treat malaria is pasak bumi roots. The purposes of this study are to determine the antimalarial activity, mechanism of action, effective dose, and toxicity of E.longifolia root. Method used in this study is searching through the journal and literature from electronic media or textbook. This study concludes E.longifolia Jack exhibited very good antiplasmodial activity against P.falciparum. Combination treatment of E.longifolia with artemisin by oral administration showed a significant parasitemia suppression as compared to artemisin treatment alone. E.longifolia inhibit protein synthesis in the malaria parasite. E.longifolia inhibited protein synthesis more rapidly than nucleic acid synthesis in human erythrocyte. E.longifolia also reduce the GSH content of healthy erythrocytes. The antimalarial effect was a consequence of the death of the host cell due to inhibition of the human enzyme. The effective dose in human is unknown. The results of acute toxicity test after giving the single dose extract showed that the fifty percent of lethal dose (LD50) is 5000 mg/kg BW. High doses (3000mg/kg BW and 15000 mg/kg BW) standardized pasak bumi root extract caused changes in histopathological picture in liver, kidney, and lung. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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