Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic  

Oleh:

Chavarro, Jorge E. ; Toth, Thomas L. ; Wright, Diane L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 07 (May 2010), page 2222-2231.
Topik: BMI; obesity; semen analysis; sperm DNA; hormones; infertility

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To examine the association between body weight and measures of male reproductive potential. Design Cross-sectional study. Setting Fertility clinic in an academic medical center. Patient(s) Four hundred eighty-three male partners of subfertile couples. Intervention(s) None. Main Outcome Measure(s) Standard semen analysis, sperm DNA fragmentation, and serum levels of reproductive hormones. Result(s) As expected, body mass index (BMI) was positively related to estradiol levels and inversely related to total testosterone and sex hormone-binding glogulin (SHBG) levels. There was also a strong inverse relation between BMI and inhibin B levels and a lower testosterone:LH ratio among men with a BMI =35 kg/m2. Body mass index was unrelated to sperm concentration, motility, or morphology. Ejaculate volume decreased steadily with increasing BMI levels. Further, men with BMI =35 kg/m2 had a lower total sperm count (concentration × volume) than normal weight men (adjusted difference in the median [95% confidence interval] = -86 × 106 sperm [-134, -37]). Sperm with high DNA damage were significantly more numerous in obese men than in normal-weight men. Conclusion(s) These data suggest that despite major differences in reproductive hormone levels with increasing body weight, only extreme levels of obesity may negatively influence male reproductive potential.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali