Analysis of the transforming growth factor ß1 gene -509 C/T polymorphism in patients with advanced-stage endometriosis  

Oleh:

Jin Ju, Kim ; Young Min, Choi ; Seon Ha, Choung

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 07 (May 2010), page 2121-2124.
Topik: Endometriosis; transforming growth factor ß1; polymorphism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate whether the transforming growth factor beta (TGF-ß) gene -509 C/T polymorphism is associated with susceptibility to advanced-stage endometriosis. Design Case-control study. Setting University department of obstetrics and gynecology. Patient(s) Women with advanced-stage endometriosis (n = 485) and without endometriosis (n = 352). Intervention(s) Genotyping by real-time polymerase chain reaction using a Taqman assay. Main Outcome Measure(s) Genotype distribution and allele frequency of the -509 C/T polymorphism in the TGF-ß1 gene. Result(s) The genotype distribution of the TGF-ß1 gene -509 C/T polymorphism in the endometriosis group was not different from that of the control group (CC/CT/TT rates were 29.3%/48.2%/22.5% and 27.3%/50.3%/22.4% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometrioma also revealed no significant differences in the genotype distribution between each of the subgroups and the control group. Conclusion(s) These results suggest that the TGF-ß1 -509 C/T polymorphism may not be associated with an increased risk for advanced-stage endometriosis.

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