A prospective, randomized trial on the effect of atmospheric versus reduced oxygen concentration on the outcome of intracytoplasmic sperm injection cycles  

Oleh:

Kovacic, Borut ; Sajko, Mojca Cizek ; Vlaisavljevic, Veljko

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 94 no. 02 (Jul. 2010), page 511-519.
Topik: Embryo development; low oxygen; poor responders; pregnancy rate; prospective randomized study

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To assess whether the embryo cultivation at different oxygen tensions had any effect on intracytoplasmic sperm injection (ICSI) outcome. Design Prospective randomized trial. Setting University clinical center. Patient(s) Women undergoing ICSI (n = 647). Intervention(s) Culturing of embryos, either at 6% CO2, 5% O2, 89% N2, or at 6% CO2 in air. Main Outcome Measure(s) The primary outcome was ongoing pregnancy rates (PR). Secondary outcomes: cumulative PRs, implantation, and embryo quality, for both treatment groups and clinical outcomes for subgroups (optimal cycles, poor responders, older women). Result(s) Although low oxygen resulted in a higher proportion of good day 2 embryos (0.547 ± 0.021 vs. 0.39 ± 0.019) and optimal blastocysts (0.162 ± 0.199 vs. 0.083 ± 0.128), the ongoing PRs (31.6% vs. 27.1%) and implantation rates (28.8% vs. 25.2%) were similar in both oxygen groups. Low oxygen caused a higher cumulative PR (38% vs. 28.3%) in the main group and a higher PR in the poor responder subgroup (23% vs. 9.8%) with embryo transfers performed mostly on day 3. Conclusion(s) The use of reduced oxygen in IVF is reasonable, irrespective of the duration of embryo culture. It improves embryo development and cumulative PR and is also recommended in poor responding cycles.

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