Prolactinoma induced by estrogen and cyproterone acetate in a male-to-female transsexual  

Oleh:

Garcia-Malpartida, Katherine ; Martin-Gorgojo, Alejandro ; Rocha, Milagros

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 94 no. 03 (Aug. 2010), page 1097.
Topik: Cross-sex hormone therapy; cyproterone acetate; estrogens; hyperprolactinemia; male-to-female transsexual; prolactinoma

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To report a case of a microprolactinoma in a male-to-female transsexual treated with estrogens and cyproterone acetate. Design Case report. Setting Endocrinology unit in a university hospital. Patient(s) A 33-year-old male-to-female transsexual with prolactin level of 10 ng/mL. Intervention(s) Treatment with equine-conjugated estrogens (2.5 mg/day, orally) and cyproterone acetate (100 mg/day, orally) during 6 months. Main Outcome Measure(s) Her levels of prolactin were repeatedly found to be elevated to a maximum of 133 ng/mL, and magnetic resonance imaging (MRI) revealed a pituitary mass of 5 × 4 × 4 mm. Result(s) Discontinuation of the cross-sex hormone treatment did not reduce the levels of prolactin. The use of dopaminergic-agonist therapy normalized them and reduced the size of the microadenoma. After sex-reassignment surgery, she was treated with low-dose estradiol transdermal patches and presented normal levels of prolactin and appropriate levels of 17ß-estradiol and testosterone with a stable image in MRI. Conclusion(s) We report a case of prolactinoma after treatment with equine-conjugated estrogens and cyproterone acetate. We recommend long-term follow-up observation consisting of a periodic evaluation of prolactin levels and any symptoms suggestive of hyperprolactinemia to detect as early as possible complications derived from cross-sex hormone therapy.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali