Genic expression of the uterine leiomyoma in reproductive-aged women after treatment with goserelin  

Oleh:

Borsari, Rodrigo ; Bozzini, Nilo ; Junqueira, Consuelo Rodrigues

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 94 no. 03 (Aug. 2010), page 1072-1077.
Topik: Genic expression; gonadotropin release hormone; microarray; uterine leiomyoma

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To identify the genes presenting different expression in uterine leiomyomas after goserelin treatment. Design Retrospective analyses of tissue obtained in a prospective clinical study. Setting School of Medicine of the University of São Paulo. Patient(s) 30 nulliparous black women aged 20 to 45 years with symptoms of uterine leiomyoma, uterine volume over 300 mL, and surgical indications for myomectomy. Intervention(s) Fifteen patients were given a monthly dose of 3.6 mg of goserelin over 3 months before surgery (group A), and 15 patients underwent surgery without any previous treatment (group B). Five random samples from each group were analyzed using the microarray technique with the Affymetrix platform (GeneChip Rat Genome 230 2.0 Array). Main Outcome Measure(s) Quantification of transcript expression levels of uterine fibroids in patients treated or not treated with goserelin. Result(s) Of the total of 47,000 sequences that were analyzed, representing approximately 38,500 human genes already characterized, we found a differential expression of 174 genes. Of these, 70 were up-regulated (33 genes with known function) and 104 were down-regulated (65 genes with known function) in samples from group A (treated) when compared with group B (nontreated). Conclusion(s) The genic expression of uterine leiomyomas changes in women who have had goserelin treatment when compared with nontreated patients.

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