Dynamics and mechanisms of chemotherapy-induced ovarian follicular depletion in women of fertile age  

Oleh:

Rosendahl, Mikkel ; Andersen, Claus Yding ; Freiesleben, Nina la Cour

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 94 no. 01 (Jun. 2010), page 156-166.
Topik: Ovarian reserve; chemotherapy; ovarian function; anti-Müllerian hormone; AMH

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To study ovarian follicular dynamics during chemotherapy to understand the mechanisms behind chemotherapy-induced ovarian follicular depletion and to evaluate whether pretreatment levels of ovarian reserve markers were predictive of the posttreatment levels. Design Prospective clinical study. Setting University hospital fertility center. Patient(s) Seventeen women (median age 30 years; range 19–35 years) undergoing chemotherapy. Intervention(s) Patients were seen before, frequently during, and after chemotherapy, until 1 year after the end of treatment. Antral follicle count and levels of FSH, LH, E2, anti-Müllerian hormone (AMH), and inhibin A and B were monitored at each visit. Main Outcome Measure(s) The dynamics of the ovarian reserve markers during chemotherapy and factors predictive of posttreatment ovarian function. Result(s) Anti-Müllerian hormone level (mean ± 2 SEM) dropped from 2.7 ± 1.0 to 1.1 ± 0.6 and to 0.4 ± 0.4 ng/mL immediately after one and two series of chemotherapy, respectively. Inhibin B and antral follicle count decreased after three series whereas FSH reached menopausal levels after four series. High pretreatment AMH levels predicted higher posttreatment AMH levels. Conclusion(s) Anti-Müllerian hormone and inhibin B levels immediately declined in response to chemotherapy, and the follicular target of chemotherapy appeared to be growing follicles. High pretreatment AMH levels were predictive of a higher posttreatment AMH level.

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