Fibrosis Hati  

Oleh:

Adhika, Oeij Anindita

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Jurnal Kedokteran MARANATHA vol. 8 no. 2 (Feb. 2009), page 198-210.
Topik: liver fibrosis; hepatic stellate cell; cytokines; growth factors; antifibrotic strategies

Ketersediaan

Perpustakaan FK Nomor Panggil: J24.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Liver fibrosis is the excessive accumulation of an extracellular matrix proteins that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and often requires liver transplantation. The knowledge of the cellular and molecular mechanisms of liver fibrosis has greatly advanced This paper describes some molecular events that occur following hepatic stellate cell activation and its role in fibrogenesis. Reversibility of advanced liver fibrosis in patients has been recently documented, which has stimulated researchers to develop anti fibrotic drugs. Emerging anti fibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans are unknown. This review summarizes recent progress in the study of the pathogenesis and diagnosis of liver fibrosis and discusses current anti fibrotic strategies.

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