COMPARISON OF APOPTOSIS IN CONTRALATERAL RENAL TUBULAR CELLS IN ORYCTALAGUS CUNICULUS DUE TO ARTIFICIAL UNILATERAL URETERAL OBSTRUCTION, WITH AND WITHOUT VERAPAMIL  

Oleh:

Boetoro, Djoyo Marsiono ; Soetojo ; Soebadi, Doddy M.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Jurnal Urologi Indonesia (Indonesian Journal of Urology) vol. 17 no. 02 (Jul. 2010), page 31-37.
Topik: Obstructive uropathy; verapamil; apoptosis

Ketersediaan

Perpustakaan FK Nomor Panggil: J33.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To study the effects of verapamil on the kidney affected by contralateral obstruction of the ureter. Material & method: The right ureter of oryctalagus cuniculus rabbits, were obstructed surgically with a silk suture, and kept alive for 14 days. The control group was obstructed without other treatment, the study group was given verapamil from day 7 until day 14 of the obstruction. A third group was obstructed and given verapamil from day 0 through day 14. The fourth was given a sham operation as control. The contralateral kidney of all groups were removed after 14 days and processed with ApopTag. The number of apoptotic tubular cells was then reevaluated and compared in each group. Results: The highest increase in apoptotic cells was in the obstructed group without verapamil, and significantly increased compared to control (p<0,001). The groups which received verapamil had a lower increase of apoptotic tubular cells. In the group with verapamil for 14 days it was lower than the group which received verapamil only for 7 days. Both the 7 to 14 and the 0 to 14 groups were significantly lower than the group without verapamil (p=0,035 and p<0,001 respectively). Conclusion: verapamil has a protective effect on the contralateral kidney by inhibiting apoptosis caused by unilateral ureter obstruction. While the definitive treatment for urinary obstruction is to relieve it, verapamil can protect the kidney in the mean time.

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