Differential association of [11C]PIB and [18F]FDDNP binding with cognitive impairment  

Oleh:

Tolboom, N. ; Flier, W. M. van der ; Yaqub, M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Neurology (Official Journal of The American Academy of Neurology) vol. 73 no. 24 (Dec. 2009), page 2079-2085.
Topik: amyloid-ß; Alzheimer disease; mild cognitive impairment; Trail Making Test

Ketersediaan

Perpustakaan FK Nomor Panggil: N11.K.2009.08 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To evaluate associations of [11C]Pittsburgh compound B (PIB) and [18F]FDDNP with impairment in specific cognitive domains over the broader spectrum comprising cognitively normal elderly subjects, patients with mild cognitive impairment (MCI), and patients with Alzheimer disease (AD). Methods: Twelve patients with AD, 13 patients with MCI, and 15 cognitively normal elderly subjects were included. Paired [11C]PIB and [18F]FDDNP PET scans were performed in all subjects. Binding potential (BPND) was calculated using parametric images of BPND for global, frontal, parietal, and temporal cortex; medial temporal lobe; and posterior cingulate. Cognitive functions were assessed using a battery of neuropsychological tests. Linear regression analyses were used to assess associations of [11C]PIB and [18F]FDDNP binding with cognitive measures. Results: Adjusted for age, sex, and [18F]FDDNP binding, higher global [11C]PIB binding was associated with lower scores on the Mini-Mental State Examination, immediate and delayed recall of the Rey Auditory Verbal Learning Task (RAVLT), Visual Association Task, and Trail Making Test part B. Conversely, higher [18F]FDDNP binding was independently associated with lower scores on immediate recall of the RAVLT. After additional adjustment for diagnosis, higher [11C]PIB binding remained independently associated with delayed recall (standardized ß = –0.39, p = 0.01), whereas higher [18F]FDDNP binding remained independently associated with immediate recall (standardized ß = –0.32, p = 0.03). When regional binding was assessed using stepwise models, both increased frontal [11C]PIB and temporal [18F]FDDNP binding were associated with memory, whereas increased parietal [11C]PIB binding was associated with nonmemory functions. Conclusion: Increased [18F]FDDNP binding is specifically associated with impairment of episodic memory, whereas increased [11C]Pittsburgh compound B binding is associated with impairment in a broader range of cognitive functions.

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