ß-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia  

Oleh:

Bourgeat, P. ; Chetelat, G. ; Villemagne, V. L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Neurology (Official Journal of The American Academy of Neurology) vol. 74 no. 02 (Jan. 2010), page 121-127.
Topik: Alzheimer disease; amnestic mild cognitive impairment; white matter

Ketersediaan

Perpustakaan FK Nomor Panggil: N11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To investigate whether global and regional ß-amyloid (Aß) burden as measured with 11C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD). Methods: Ninety-two elderly healthy controls, 32 subjects with aMCI, and 35 patients with AD were imaged using 11C-PIB PET and MRI. Hippocampal volume was measured and PIB standardized uptake value ratio was extracted after partial volume correction within 41 regions of interest. Global, regional, and voxel-based correlations between PIB and hippocampal volume were computed for each group. Results: In healthy control participants with elevated neocortex PIB retention, significant correlation was found between PIB retention in the inferior temporal region and hippocampal volume using both region-based and voxel-based approaches. No correlation was found in any other group. Conclusions: The strong correlation between hippocampal atrophy and ß-amyloid (Aß) burden in the Pittsburgh compound B–positive healthy control group suggests that Aß deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration.

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