Detail Pengaruh Kolestasis Ekstrahepatik Akut dan Kronik Terhadap Peningkatan Kadar Serum Glutamic Oxaloacetic Transaminase (SGOT) Pada Tikus Sprague-Dawley Jantan Bibliografi Author: ISKANDAR, FERDY ; Sidharta, Veronika Maria (Advisor); Bororing, Sheella Rima (Advisor); Harjanti, Dyonesia Ary (Examiner) Topik: LIVER; SGOT; acute and chronic extrahepatic cholestasis; rats; Sprague-Dawley; ligation; kolestasis ekstrahepatik akut dan kronik; tikus; ligasi Bahasa: (ID )     Penerbit: Fakultas Kedokteran Unika Atma Jaya     Tempat Terbit: Jakarta Utara    Tahun Terbit: 2014     Jenis: Theses - Karya Tulis Ilmiah Kedokteran (KTI-FK) Fulltext: Ferdy_Iskandar_KTI_2014.pdf (1.51MB; 1 download) Ketersediaan Perpustakaan FK Nomor Panggil: KTI-FK-683 Non-tandon: tidak ada Tandon: 1  Lihat Detail Induk Abstract Background. Liver is the largest gland and metabolism organ in human body which has function to secrete bile. If there is any bile flow obstruction, the symptoms of cholestasis will appear. Various studies using models of cholestasis were conducted to evaluate hepatic dysfunction, including assessing the degree of damage to hepatocytes using SGOT levels. Objectives. To measure the levels of SGOT in rats with acute and chronic extrahepatic cholestasis and to assess the relationship of the length of treatment to the elevation of SGOT levels. Methodology. This research is an experimental in vivo study and implemented cross-sectionally. Rats were dissected, their common bile ducts were ligated, blood samples and serum were taken and checked using Microlab 300. The total samples were 24 rats. Data collection was performed twice on 7-day post-ligation (acute extrahepatic cholestasis) and 21-day post-ligation (chronic extrahepatic cholestasis, each with control and experimental groups. Data analysis was performed using independent t-test with 95% confidence level (a=0,05). Results and Conclusions. All of the groups of rats in this study have elevated SGOT levels. There are significant elevation of SGOT levels in each acute and chronic extrahepatic cholestasis group to control group (p=0.000Suggestion. The measurement of SGOT levels in all groups of rats should also be done before conducting the study to get the initial reference value of SGOT, given the lack of reference of normal SGOT levels in rats in Indonesia. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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