Reduced Bone Mineral Density and Serum C-Telopeptide Concentration in HIV-infected Patients in Cipto Mangunkusumo Hospital  

Oleh:

Setyohadi, Bambang ; Mulansari, Nadia A. ; Sukmana, Nanang

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Acta Medica Indonesiana vol. 41 no. 04 (Oct. 2009), page 191-194.
Topik: bone mineral density. serum Cstetopeptide. HIV patients; CD4 count

Ketersediaan

Perpustakaan FK Nomor Panggil: A02.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Aim: to evaluate BMD and bone resorption marker in HIV-infected patients in Cipto Mangunkusumo Hospital, Jakarta. Methods: a cross-sectional study was performed between February and May 2008 in adult HIV-infected patients who had not been treated with antiretrovirals. BMD was measured at the lumbar spine by dual energy X-ray absorptiometry (DEXA) bone densitometer (Lunar Prodigy, GE Medical System. USA). whereas CTX (Csterminal telopeptide) was measured by an automated analyzer (Elecsys 2010, Roche Diagnostics GmbH. Mannheim, Germany) using the b-Crosslaps serum reagents. Results: fourty-two patients were included. comprising 31 (73.8%) men and 11 (26.2%) women. Patients' median age was 28 years, ranging from 22 to 39 years old. The peak age group was 26-30 years old. Low BMD (osteopenia) was found in 11 (26.2%) of patients. Mean serum CTX level was significantly correlated with BMD (r=0.446; p=O. 003). Conclusion: patients with low CD4 count and low BMI tended to have higher serum CTX HIV-infected, treatment-naive patients possess a significant risk for reduced BMD due to increase bone resorption activity. Further studies are needed to evaluate the association of disease severity and bone resorption markers.

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