Increased Heme Oxygenase-1 Gene Expression in the Livers of Patients with Portal Hypertension due to Severe Hepatic Cirrhosis  

Oleh:

Matsumi, M ; Takahashi, T. ; Fujii, H.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 30 no. 03 (May 2002), page 282-288.
Topik: hepatic transplantation; portal hypertension; liver cirrhosis; heme oxygenase-1; non-specific d-aminolevulinate synthase; gene expression

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Surgical bleeding associated with splanch­nic hyperaemia due to portal hyper­tension complicates the anaesthetic man­agement of hepatic transplantation. Although the mech­anism(s) of portal hyper­tension are not fully understood, carbon monoxide, a product of the heme oxygenase (HO) reaction, is thought to be one of the endogenous vasodilators in the liver. In this study, the expression of mRNA encoding inducible HO isozyme (HO-1) in the livers of patients with portal hyper­tension under­going hepatic trans­plan­tation was determined in comparison with those without portal hypertension. HO-1 mRNA levels were significantly greater in the portal hyper­tension group than in the group without portal hypertension. In contrast with HO-1, the gene expression of non-specific d-amino­levulinate synthase (ALAS-N), which is down-regulated by heme in the liver, was the same in both groups. These results suggest that HO-1 is up-regulated through heme-independent stimuli accord­ing to the development of portal hyper­tension, and that induced HO-1 plays a pathophysio­logical role in portal hyper­tension through carbon monoxide production.

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