Background: Hypercholesterolemia is a serious threat to global health. The prevalence of hypercholesterolemia increased annually, especially hypercholesterol is a risk factor for heart disease, which has been ranked number one cause of death in developed countries. Alternative compounds in the prevention of hypercholesterolemia is needed. Garlic {Allium sativum) is a medicinal plant that has been shown to lower total cholesterol in patients with hypercholesterolemia. However, there has not been known the preventive effect of garlic. Therefore, formed an idea that underlies this study entitled "The Effect of Garlic {Allium sativum) on Prevention of Hypercholesterolemia in Rats".
Method: The experiment was using 28 Sprague Dawley rats which were divided into a control group, a group of low-dose given of garlic (125mg/ kg/day/rat), a group of moderate doses given of garlic (250mg/kg/day/rat), and a group of high doses of given garlic (500mg/kg/day/rat). After the rats received feed garlic for 14 days, 14 days more the diet werw added with the yolk. Rat's blood was collected 3 times, the baseline, day 15, and the end of the study. Blood sampling through cutting the distal part of the rat's tail for the examination of total cholesterol level.
Result: Data were collected and analyzed using SPSS 15. Based on the paired f-test found that total cholesterol levels were not significantly different between before treatment and after treatment which was given garlic for 14 days and then added with egg yolk in garlic low-dose (p = 0.778, difference = -1.571 + 14.070 , 95% CI = -14.584 a 11.441), moderate dose (p = 0.688, difference = 13.447 ± 2.143, 95% CI = -10.293 a 14.579), high dose (p =0.877, difference = 11.701 ± 0.714, 95% CI a 11.536 = -10.107).
Conclusion: The results showed that administration of low doses of garlic (125mg/kgBB), moderate (250mg/kgBB), and high (500mg/kgBB) capable of preventing hypercholesterolemia. The dose is not recommended due to high doses caused a significant decrease in normal total cholesterol level. While the recommended dosage is low dose. |