A comparison of 5 or 7 days of rabeprazole triple therapy for eradication of Helicobacter pylori  

Oleh:

Syam, Ari Fachrial ; Abdullah, Murdani ; Rani, Abdul A.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Medical Journal of Indonesia vol. 19 no. 02 (May 2010), page 113-117.
Topik: H. pylori; rabeprazole; triple therapy

Ketersediaan

Perpustakaan FK Nomor Panggil: M35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Aim A combination of PPI and 1000 mg amoxicillin/500 mg clarithromycin twice daily for 2 weeks has been proven effective in the eradication of H pylori. Most studies suggested that treatment for 7 and 10 days may be equally effective. Few data are available on the efficacy of 5-day triple therapy. Aim of this study was to compare 5-day and 7-day rabeprazole triple therapy for eradication of H pylori infection. Methods We prospectively studied 60 consecutive H pylori-infected patients who came to hospitals in six centres in Indonesia and who underwent upper endoscopy and biopsy. H pylori infection was confirmed if two rapid urease tests (Pronto Dry) and histology or urea breath test were positive. Patients were assigned to either an open-labelled 5-day or 7 -day course of oral amoxicillin 1000 mg b.i.d., clarithromycin 500 mg b.i.d., and rabeprazole 10 mg b.i.d. (RAC). Four weeks after therapy, all patients had a repeated UBT for evaluation of the presence of H pylori. Results Ofthe 60 patients (42 males and 18 females) with mean age (± SD) 47.63 ± 13.93 years, range 21-74 years, 25 patients (41.7%) had 5-day treatment and 35 patients (58.3%) had 7-day treatment. With 5-day treatment, 18 patients (72%) and with 7-day treatment 32 patients (91.4%) became negative for H pylori infection. The eradication failure was found on 7 patients (28.0%) in 5-day treatment and 3 patients (8.6%) in 7-day treatment. Conclusions The study showed that the eradication of H pylori infection by triple rabeprazole-based treatment in 7-day is still better than in 5-day.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali