Differences between several atherogenic parameters in patients with controlled and uncontrolled type 2 Diabetes Mellitus  

Oleh:

Susanti, Ellis ; Donosepoetro, Marsetio ; Patellongi, Ilhamjaya ; Arif, Mansyur

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Medical Journal of Indonesia vol. 19 no. 02 (May 2010), page 103-108.
Topik: AIP; atherosclerosis; Diabetes mellitus; HDL; Lp-PLA2; Ox-LDL

Ketersediaan

Perpustakaan FK Nomor Panggil: M35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Aim to assess the differences between Atherogenic Index of Plasma (AlP), ratio of oxidized-Low Density Lipoprotein (Ox-LDL)/High Density Lipoprotein (HDL) and ratio of Lipoprotein-associated Phospholipase A2 (Lp-PLA2)/HDL in predicting the risk of coronary heart disease (CHD) in patients with controlled and uncontrolled type 2 Diabetes Mellitus (T2DM). Methods The study was done observationally with cross sectional design. A total of 80 patients, consisted of 40 controlled and 40 uncontrolled T2DM. The serum triglyceride (TG), HDL-C, Ox-LDL, Lp-PLA2 were examined in their relationship with T2DM risk. AIP is a ratio calculated as log (TGIHDL-C). Results AlP and ratio of Ox-LDL/HDL were significantly higher in uncontrolled than controlled T2DM (0.72 + 0.13 vs 0.47 ± 0.22, p < 0.001) and (1738.8 ± 625.5 vs 1418 ± 535.3, p = 0.02), but no significant difference was found in ratio of Lp-PLA2/HDL (5.09 ± 2.17 vs 5.95 ± 3.11, p = 0.16). Conclusion AlP and ratio of Ox-LDLIHDL value were significantly higher in uncontrolled than in controlled TIDM. These parameters may be beneficial in predicting the risk of atherosclerosis in diabetic patients.

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