Effects of BCG vaccination prior to specific immunotherapy on IL-4/IFN- ratio and AR total symptom score in persistent allergic rhinitis  

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Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Media Medika Indonesiana vol. 43 no. 06 (Sep. 2009), page 294-299.
Topik: BCG vaccination; specific immunotherapy; allergic rhinitis

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Perpustakaan FK Nomor Panggil: M30.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Background: Allergic disease including allergic rhinitis (AR) is dominated by Th2 responses with increased production of IL-4 and inhibition of IFN-? production. BCG vaccination induced IL-12 production which promotes Th0 to Th1 shift and stimulates IFN-? production. The aim of this study is to determine whether BCG vaccination prior specific immunotherapy (SIT) could increase initial phase of SIT responses measured by decreasing IL-4/IFN-? ratio 's and AR total symptom score (TSS). Method: This study was carried out by a randomized controlled trial. A total of 84 patients with moderate to severe persistent AR were randomized and assigned into 4 treatment groups (BCG solvent, BCG vaccination, SIT, and BCG vaccination prior SIT). A subcutaneous SIT was given using mixed house dust mite extract (D pteronyssinus and D farinae, 50/50), while BCG vaccination was given by intracutaneous injection. Clinical symptoms and concentrations of IL-4 and IFN-?were measured by PHA stimulated fresh whole blood culture, before and after 8 weeks of SIT. Result: There were no significance difference between the concentrations of IL-4 and IFN-?, and their ratio in all four groups. However, there is a significant lower IL-4/IFN-? ratio in the group with pretreatment of BCG than SIT (p=0.024), while during the initial phase, AR symptoms in patients who received BCG prior SIT is significantly lower than SIT (p=0.027). Conclusion: This study demonstrates that BCG vaccination prior to SIT treatment could increase initial phase of SIT responses in persistent allergic rhinitis without additional adverse effects.

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