CD38 LIMFOSIT CD8+, TAMPANG (PROFIL) CD4+, DALAM KEADAAN (STATUS) IMUNOLOGIS DAN KLINIS PENGOBATAN ANTIRETROVIRAL PENDERITA HIV / AIDS  

Oleh:

Puspitawati, Ira ; Intansari, Umi S.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 16 no. 01 (Nov. 2009), page 32-35.
Topik: CD38; immune activation; HN/AIDS; CD8+ cells; CD4+ cells

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The relationship between immune activation and pathogenesis of Human Immunodeficiency Virus (HIV) infection is unproven. It has been hypothesized that state that HN-induced activation enhances the magnitude of HN replication other study shown that viral replication impaired immune activation. One of the best immune activation marker is CD38 expression on CD8 because it has the strongest significant prognostic markers. It was previously shown that increased CD8+ T-cell activation has predictive value for disease progression but the relation is still controversial. One hypothesis state that HN-induced activation enhances the magnitude of HN replication, other said that viral replication impaired immune activation. To know the profile of immunology and clinical state of HN/ AIDS patients by determining the CD38 molecule expression on CD8+ cells as an activation marker, CD4+ profiles and clinical state. Crosssectonal, observasional study was done. twenty nine HN/AIDS patients who routinely had medical check up and having routine antiretroviral therapy at Sardjito hospital and 8 healthy people as normal controls were involved in this study. The count of CD4+ cells absolute counts and expression of CD38 molecule on CD8 cells were measured using flowcytometry. The CD4+ counts had significant negative correlation with WHO stage (p = 0.012). Expression of CD38 molecule on CD8+ cells of HIV/AIDS patients were higher compared to normal controls, 209.29 ± 76.56, 109.61 + 32.29 respectively (p < 0.05). That expression was not correlated with CD4+ counts and CD4+ increment. It might be caused by the time of measurement was not at the begining of diseases. The CD4+ increment after therapy was statistically significant (p = 0.003). The CD4+ count was negatively correlated with the WHO stage. Expression of CD38 molecule on CD8+ cells of HN/AIDS patients were significantly higher compared to normal controls but it wasn't correlated with the CD4 number and CD4+ increment after therapy.

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