Toll-like Receptor (TLR) dan Imunitas Natural  

Oleh:

Ma'at, Suprapto

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 15 no. 03 (Jul. 2009), page 111-116.
Topik: toll-like receptor; imunitas natural

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

In all living species, the first line of defence against microbial aggressions is constituted by innate immunity. Toll-like receptors (TLRs) are a family of pattern recognition receptors that are activated by specific components of microbes and .certain. host molecules. They constitute the first line of defense against many pathogens and play a crucial role tn the function of the innate Immune system. Recognition of pathogen-associated molecular pattern (PAMP) by TLR, alone or heterodimerization with other TLR or non-TIR receptors, induces signals responsible for the activation of genes important for an effective host defense, especially proinflammatory cytokines, or initiates signal transduction pathways, which trigger expression of genes. These gene products control innate immune responses and further instruct development of antigen-specific acquired immunity.

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