Anti-Intercellular Adhesion Molecule-1 (ICAM-1) Antibody Treatment Prevents Central and Peripheral Nervous System Disease in Autoimmune-Prone Mice  

Oleh:

Brey, RL ; Amato, AA ; Hallet, K. Kagan ; Rhine, CB ; Stallworth, CL

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 6 no. 8 (1997), page 645-651.
Topik: Intercellular Adhesion Molecule-1; MRL/1pr Mice; Systemic Lupus Erythematosus; Nerve Conduction Studies
Fulltext: 645.full.pdf (799.03KB)

Isi artikel

Abnormal neurological functioning similar to that seen in systemic lupus erythematosus (SLE) patients is detectable in an SLE-prone murine strain (MRL/1pr) by 8-10 weeks and is severe by 18 weeks of age. The purpose of this study was to evaluate the effectiveness of murine antiintercellular adhesion molecule-1 (ICAM-1) in suppressing neurological disease in MRL/1pr mice. Beginning at 6 weeks of age, five MRL/1pr mice received 5 weekly intraperitoneal injections of anti-ICAM-1-containing culture supernatant in phosphate-buffered saline (PBS) whereas four animals were treated with non-anti-ICAM-1 containing supernatant in PBS. A decline in neurological functioning began in control mice by 10 weeks, but anti-ICAM-1 treated mice remained normal throughout the study. All control mice had vasculitic skin lesions by 14 weeks of age whereas none of the anti-ICAM-1 treated mice ever developed skin lesions. Nerve conduction studies performed on all mice prior to sacrifice showed sciatic compound motor action potentials of anti-ICAM-1 treated mice that were of higher amplitude and shorter latency than those of controls. Inflammation in the sciatic nerve was more common in control mice. Brain histology revealed a similar degree of choroid plexus inflammation in both groups. Our study demonstrated that anti- ICAM-1 was effective in suppressing neurological abnormalities in MRL/1pr mice and may potentially be useful therapy in human SLE.

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