Detail Acute and Chronic Toxicity of Moringa oleifera Linn Leaves Extracts Bibliografi Author: Chivapat, Songpol ; Sincharoenpokai, Pornchai ; Saktiyasuthorn, Nalinphat ; thongsrirak, Pratom ; Sakpetch, Apirak ; Rungsipipat, Anudep Topik: M. oleifera leaves extract; acute; chronic toxicity; mice; rat Bahasa: (EN )     Tahun Terbit: 2011     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: Acute and Chronic Toxicity of Moringa oleifera Linn leaves extracts.pdf (386.57KB; 1 download) Abstract Moringa oleifera leaves have been reported to possess potential hypotensive and hypocholesterolemic and hypoglycemic activities; nevertheless toxicological data of this herb in animal models have still been scanty. The objective of this study was to evaluate both acute and chronic toxicity of the water extract of M. oleifera leaves by oral administration. Acute toxicity test in mice by gavage with the extract twice, each at the dose of 10 g/kg, revealed that the extract produced no acute toxic symptoms and gross lesions of vital organs. Chronic toxicity study was investigated in eighty Wistar rats allocated into four groups, each of ten per sex. Group 1 was the control group receiving distilled water. Group 2 to 4 were experimental groups receiving the extract at the doses of 10, 100 and 1000 mg/kg/day for six months consecutively. The results revealed that the extract at different doses did not affect growth, food consumption, general health status and any hematological values of the animals. Blood chemistry profiles of the extract-treated male rats were not significantly different from those of the control-group male rats. In the female, when compared to the control group, the group receiving the extract at the dose of 100 mg/kg/day had significantly higher albumin and the highest dose–treated group had significantly lower potassium levels. Histopathological results revealed that the incidence of lesions in some organs of all extract-treated groups were not significantly different from those of the control group. In conclusion, the water extract of M. oleifera leaves at the tested doses produce no acute toxicity and serious chronic toxicity in experimental animals. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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