ß-Carotene Conversion to Vitamin A Decreases As the Dietary Dose Increases in Humans  

Oleh:

Novotny, Janet A. ; Harrison, Dawn J. ; Pawlosky, Robert ; Flanagan, Vincent P.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 140 no. 05 (May 2010), page 915-918.
Topik: ß-CAROTENE; VITAMIN A

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

It has been suggested that high doses of ß-carotene limit its conversion to vitamin A, yet this effect has not been well established in humans. A feeding study was conducted in a randomized crossover design in which volunteers consumed 2 doses of deuterium-labeled ß-carotene on 2 occasions, with ß-carotene and vitamin A response assessed by plasma area under the concentration time curve (AUC). Seven volunteers (4 men, 3 women) consumed each of 2 doses of ß-carotene-d8 and provided serial blood samples for 37 d after each dose. ß-Carotene doses were 20 and 40 mg. Plasma ß-carotene-d8 was assessed by HPLC-MS. Plasma retinol (ROH)-d4, which was derived from the ß-carotene-d8, was evaluated by GC-MS after saponification to convert retinyl esters to ROH prior to the formation of the trimethylsilylether. The plasma AUC for ß-carotene-d8 increased 2-fold from the 20-mg dose to the 40-mg dose. The plasma AUC for ROH-d4 increased 36% from the 20-mg dose to the 40-mg dose. These results establish that, in humans, ß-carotene conversion to vitamin A decreases as the dietary dose increases.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali