Characteristics of T Cells That Participate in The Pathogenesis of SLE  

Oleh:

Hahn, B.H. ; Datta, S.

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 6 no. 3 (1997), page 330-332.
Topik: T Cells; Immune Tolerance; Nucleosomes; Helper T Cells; Th1 Subset; Th2 Subset
Fulltext: 330.full.pdf (265.0KB)

Isi artikel

Murine and human SLE result from abnormal functions of both B cells and T cells, so that pathogenic subsets of autoantibodies and immune complexes are generated over long periods of time, namely long enough to induce tissue damage. All of the mouse models of SLE are protected from disease by elimination or inactivation of CD4 + T cells. B cells alone are unable to secrete adequate quantities of pathogenic immunoglobulin (Ig) to induce disease. Therefore, attention has been directed to the properties of lupus CD4 + cells, with interesting results. In this portion of the symposium, several investigators characterize the properties of murine and human lupus CD4 + cells.

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