Detail Defective Phagocytosis of Apoptotic Cells: Possible Explanation for The Induction of Autoantibodies in SLE   Oleh:  Kalden, JR Jenis: Article from Journal Dalam koleksi: Lupus vol. 6 no. 3 (1997), page 326-327. Topik: Phagocytosis of Apoptotic Cells Fulltext: 326.2.full.pdf (245.03KB) Isi artikel The presentation by Dr. Kalden, Erlangen, also discussed possible mechanisms leading to the induction of anti-dsDNA antibodies, however using a different approach. Based on observations indicating that anti-dsDNA antibodies are antigen-driven,’ the Erlangen group investigated if the aberrant apoptosis as described in murine models of SLE and in SLE patients’° could be responsible (a) for a persistent increase of possible autoantigens such as nucleosomes in the plasma of SLE patients, and (b) could be involved in trigger mechanisms leading to the induction of anti-dsDNA antibodies. With regard to the increased apoptosis of PBMC of SLE patients, it has recently been demonstrated that this increase was not due to a dysregulation of apoptosis related genes in lymphocytes from SLE patients, but rather to the known increased percentage of activated T cells in the peripheral blood.1 Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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