Detail Environmental and Other Stimuli for DNA Antibody Production   Oleh:  Kalden, J. ; Marion, T.N. Jenis: Article from Journal Dalam koleksi: Lupus vol. 6 no. 3 (1997), page 324-329. Topik: Systemic Lupus Erythematosus; Anti-DNA Antibodies; Autoimmunology Fulltext: 324.full.pdf (233.14KB) Isi artikel Results from experimental models of systemic lupus erythematosus generated especially over the last eight to nine years have provided strong evidence that autoimmunity to DNA is both initiated and sustained as an antigen-driven, clonally-selected immune response to DNA. Murine autoimmune antibody responses to DNA have all of the characteristics associated with secondary immune antibody responses to foreign antigens. The autoimmune anti-DNA responses undergo isotype switching to IgG and variable-region affinity maturation for dsDNA. Although technical difficulties have limited clonotypic analyses of DNA antibodies in lupus patients, the available structural data derived from studies of human monoclonal anti-DNA antibodies are consistent with the more abundant data from mice. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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