Alterations of Serum and Placental Endoglin in Pre-eclampsia  

Oleh:

Fang, M. ; He, Y. ; Li, H. ; Wu, M

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 01 (Jan. 2010), page 43-51.
Topik: pre-eclampsia; pregnancy; endoglin; placenta; second trimester; predictors

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Serum levels of endoglin were measured in pre-eclamptic women in their third trimester and in women in their second trimester who later developed pre-eclampsia. Placental levels of endoglin at birth were also determined in pre-eclamptic women and healthy controls. Serum endoglin was significantly higher in pre-eclamptic women in the third trimester than in controls (median 35.15 versus 10.35 ng/ml, respectively) and in women with severe compared with mild pre-eclampsia (median 51.68 versus 20.99 ng/ml, respectively). Placental endoglin was also significantly higher in pre-eclamptic women than controls (median 26.24 versus 9.21 ng/mg, respectively) and in women with severe compared with mild pre-eclampsia (median 28.77 versus 13.38 ng/mg, respectively). Pregnant women in the second trimester who eventually developed pre-eclampsia had significantly higher serum endoglin than age- and gestational age-matched controls (median 5.90 versus 5.20 ng/ml, respectively). These findings suggest that endoglin plays an important role in the pathogenesis of pre-eclampsia.

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