Detail Role of Beta2-Glyceoprotein I in The Anticardiolipin Antibody Affinity for Phospholipid in Autoimmune Disease   Oleh:  Dueymes, M. ; Piette, J.C. ; Tonquèze, M. Le ; Bendaoud, B. ; Roué, R. ; Youinou, P. Jenis: Article from Journal Dalam koleksi: Lupus vol. 4 no. 6 (1995), page 477-481. Topik: Anticardiolipin Antibody; Beta2-glycoprotein I; Functional Affinity Fulltext: 477.full.pdf (445.27KB) Isi artikel The binding capacity to cardiolipin and the functional affinity of affinity-purified anticardiolipin (aCL) IgG of patients with autoimmune disease have been compared with those of individuals with malaria and acquired immunodeficiency syndrome (AIDS). The binding of autoimmune IgG aCL was enhanced gradually by the incorporation of increasing amounts of &2-glbyceoptroate;in I (2G&PbeIta); into the assay, in contrast to that of patients with infectious diseases. In addition, there were significant reductions of functional affinity in autoimmune disease, but not in malaria or in AIDS. These results indicate that &2GbePtaI; requirement for binding to the target antigen varies inversely with functional affinity in autoimmune disease when &2GbePtaI; was present, and suggest that IgG aCL are more heterogeneous in this type of disorder than in patients with infectious disease. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

Copyright © 2006, 2007 Unika Atma Jaya, all rights reserved