Clostridium difficile — More Difficult Than Ever  

Oleh:

Kelly, Ciaran P. ; LaMont, J. Thomas

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 359 no. 18 (Oct. 2008), page 1932-1940.
Topik: Clostridium difficile

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

In 1935, Hall and O'Toole first isolated a gram-positive, cytotoxin-producing anaerobic bacterium from the stool of healthy neonates. They named it Bacillus difficilis to reflect the difficulties they encountered in its isolation and culture. We now face the opposite problem of being unable to contain the growth and spread of the same bacterium, now called Clostridium difficile, which is a frequent cause of infectious colitis, usually occurring as a complication of antibiotic therapy, in elderly hospitalized patients. In this article we review recent changes in the epidemiology of C. difficile infection, discuss changes in disease severity and response to therapy, and review new approaches to the management of this increasingly problematic infectious diarrhea.

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