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IgA Antiphospholipid Antibodies in HTLV-1-Associated Tropical Spastic Paraparesis
Oleh:
Wilson, Wendell A
;
Morgan, Owen St. C
;
Barton, EN
;
Smikle, M
;
Handchard, B
;
Blattner, WA
;
Doggett, Sarah
;
Gharavi, Azzudin E
Jenis:
Article from Journal
Dalam koleksi:
Lupus vol. 4 no. 2 (1995)
,
page 138-141.
Topik:
Phospholipid Antibodies
;
Tropical Spastic Paraparesis
Fulltext:
138.full.pdf
(342.62KB)
Isi artikel
A retrovirus, human T cell lymphotropic virus type 1 (HTLV-1), is an essential but not a sufficient aetiologic factor for tropical spastic paraparesis (TSP). Because some TSP patients have biological false positive tests for treponemal infections (BFP-STS), we used ELISA to study BFP-STS and anticardiolipin antibodies in 42 Jamaican TSP patients. The data indicate that in TSP anticardiolipin antibodies occur in about 26% of patients, are associated with biological false positive treponemal serology, are relatively restricted to the IgA isotype and may be induced by HTLV-1 or other nontreponemal infections.
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