A new endocrinological and immunological syndrome in SLE: elevation of human Chorionic Gonadotropin and of Antibodies Directed Against Ovary and Endometrium Antigens  

Oleh:

Moncayo, Roy ; Moncayo, Helga E

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 4 no. 1 (1995), page 39-45.
Topik: Systemic Lupus Erythematosus; Human Chorionic Gonadotropin; Ovarian Autoimmunity; Prolactin; Endometrium
Fulltext: 39.full.pdf (706.29KB)

Isi artikel

We have analysed the levels of gonadotropins in male and female patients with systemic lupus erythematosus (SLE). Human chorionic gonadotropin hCG was elevated in 23.8% of patients compared with 12.7% of controls. hCG isolated from the serum of SLE patients was bioactive in vitro. Levels of hCG were significantly correlated with those of its beta-subunit but not with the levels of follicle stimulating hormone, luteinizing hormone, prolactin alphafetoprotein or carcino embryonic antigen. A high percentage of patients presented an organ-specific humoral immune response against ovarian (26.7%) and endometrial (40%) antigens compared with controls (8% and 7.6%, respectively). Endometrial antibodies were significantly correlated to the levels of prolactin. The ovarian tumour marker CA-125 was elevated in 32.5% of patients, including two males. As a whole, these elements delineate a new endocrine and immunological syndrome in SLE in which the elevation of hCG could provide a central physiological explanation for a series of endocrine alterations that characterize this disease.

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