Detail Antiphospholipid Antibodies and Thrombosis: Assessment of The Potential Risk for Thrombosis   Oleh:  Salem, HH Jenis: Article from Journal Dalam koleksi: Lupus vol. 5 no. 2 (1996), page 163-166. Topik: Lupus Anticoagulent; Protein C; Activated Protein C Resistance Fulltext: 163.full.pdf (382.04KB) Isi artikel Antiphospholipid antibodies represent a large group of clinically significant antibodies. They are usually detected by the prolongation of phospholipid dependent coagulation assays (The lupus anticoagulant tests), or immunologically using cardiolipin as the target antigen (The anticardiolipin antibody test)’. Although the term antiphospholipid antibody implies a direct interaction between the antibody and phospholipid, the exact target antigen(s) is not known. Recent studies suggest that the antibody is more likely to be directed against a protein/lipid complex. A variety of proteins have been implicated in this regard. These include fJ2- glycoprotein 12, prothrombin’, annexin4, protein C, protein S’, and high molecular weight kininogen6. The scenario is further complicated by the fact that in many patients the antibody can interact with the phospholipid in the absence of a protein cofactor. The frequency of protein (cofactor) requirement for the phospholipid-antibody interaction has led several investigators to suggest that the antibodies are best referred to as antiphospholipid/ protein antibodies. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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