Immunology of Antiphospholipid Antibodies and Their Interaction with Plasma Proteins  

Oleh:

Kandiah, DA ; Krilis, SA

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 5 no. 2 (1996), page 153-154.
Topik: Antiphospholipid Antibodies; Lupus Anticoagulants; B2-Glycoprotein I; Prothrombin
Fulltext: 153.full.pdf (331.31KB)

Isi artikel

’Antiphospholipid’ (aPL) antibodies are of clinical importance because of their strong association with vascular thrombosis, recurrent pregnancy loss, thrombocytopenia and other clinical manifestations like livedo reticularis, chorea and cardiac valvular disease While aPL antibodies have traditionally been thought to be directed against negativelycharged (anionic) phospholipids, current evidence suggests that these autoantibodies recognise protein-phospholipid complexes or the proteins them-selves A number of candidate proteins have been investigated with the two most extensively researched being B2-beta; glycoprotein I and prothrombin.

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