Hypothesis The Antiphospholipid Syndrome and SLE: Is There A Clue in The Link Between Complement and Coagulation?  

Oleh:

Merrill, JT ; Lahita, RG

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 5 no. 1B (1996), page 6-10.
Topik: Antiphospholipid; Coagulation; Complement; Systemic Lupus Erythematosus
Fulltext: 6.full.pdf (573.22KB)

Isi artikel

The heterogenous immunoglobulins known as antiphospholipid antibodies (APLA) or . lupus ’anticoagulants’ (LA) are prevalent in lupus patients and have been implicated in life-threatening thromboembolic e1.v-en3ts Unfortunately, observing the presence of these antibodies in an individual does not predict the likelihood of an event nor does it predict when it may o4.c-cu6r A pathogenic role for these antibodies is supported by the observation that high titers and IgG isotype confer an increased risk of t7.hromboembolism Additionally, numerous reports indicate that isolated patient antibodies interfere with various elements of the coagulation c8.a-sc1ad5e Nevertheless, attempts to correlate specific antibody characteristics with the future likelihood of a hypercoagulable event in an individual p1 ati6enthave been unsuccessful to date. Given such uncertainty combined with the potential complications of anticoagulant medications, patients are generally not treated until significant morbidity has occurred. Finally, because of the apparent high rate of r1 eoccur7rence most patients must remain on anticoagulant therapy indefinitely, regardless of need.

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