Detail Association Of Nuclear Localization Of A Long Interspersed Nuclear Element-1 Protein In Breast Tumors With Poor Prognostic Outcomes   Oleh:  Harris, Chris R. ; Normart, Robin ; Yang, Qifeng ; Stevenson, Elizabeth ; Haffty, Bruce G. ; Ganesan, Shridar ; Cordon-Cardo, Carlos ; Levine, Arnold J. ; Tang, Laura H. Jenis: Article from Article Dalam koleksi: Genes and Cancer vol. 1 no. 2 (May 2010), page 115-124. Topik: Line Expression; Line Movement; Breast Cancers Fulltext: 115.full.pdf (804.55KB) Isi artikel Within healthy human somatic cells, retrotransposition by long interspersed nuclear element-1 (also known as LINE-1 or L1) is thought to be held in check by a variety of mechanisms, including DNA methylation and RNAi. The expression of L1-ORF1 protein, which is rarely found in normal tissue, was assayed using antibodies with a variety of clinical cancer specimens and cancer cell lines. L1-ORF1p expression was detected in nearly all breast tumors that the authors examined, and the protein was also present in a high percentage of ileal carcinoids, bladder, and pancreatic neuroendocrine tumors, as well as in a smaller percentage of prostate and colorectal tumors. Tumors generally demonstrated cytoplasmic L1-ORF1p; however, in several breast cancers, L1-ORF1p was nuclear. Patients with breast tumors displaying nuclear L1-ORF1p had a greater incidence of both local recurrence and distal metastases and also showed poorer overall survival when compared with patients with tumors displaying cytoplasmic L1-ORF1p. These data suggest that expression of L1-ORF1p is widespread in many cancers and that redistribution from cytoplasm to nucleus could be a poor prognostic indicator during breast cancer. High expression and nuclear localization of L1-ORF1p may result in a higher rate of L1 retrotransposition, which could increase genomic instability. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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