Performance Characteristics of the New Definition of Diabetes The Insulin Resistance Atherosclerosis Study  

Oleh:

Lorenzo, Carlos ; Haffner, Steven M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 33 no. 02 (Feb. 2010), page 335-337.
Topik: DIABETES; DIABETES MELLITUS; Diabetes; Insulin Resistance Atherosclerosis

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE : A1C =6.5% has been recently proposed as the defining criterion for diabetes. However, performance characteristics of this definition have not been described. RESEARCH DESIGN AND METHODS : In the Insulin Resistance Atherosclerosis Study, we compared new to previous definitions of diabetes: 1999 World Health Organization (DM1999WHO) and 2003 American Diabetes Association based on fasting glucose alone (DMFPG126). RESULTS : Participants with A1C =6.5%, DM1999WHO, and DMFPG126 were 44 (5.2%), 132 (15.4%), and 61 (7.1%), respectively. In individuals with DM1999WHO, mean, median, and interquartile range of A1C were 6.3, 5.9, and 5.5–6.6%, respectively; in individuals with DMFPG126, mean, median, and interquartile range of A1C were 7.0, 6.6, and 6.0–7.1%. CONCLUSIONS : A1C =6.5% identifies fewer individuals than DM1999WHO or DMFPG126. Studies are needed to determine that A1C =6.5% compromises neither blood pressure and lipid management in early diabetes nor the implementation of lifestyle interventions for diabetes prevention.

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